SCHEMBL6055040

SCHEMBL6055040

Clc1ccc(-c2n[nH]c3ncncc23)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 2/20 0.41
CSNK2A2 P19784 2/20 0.40
CSNK2B P67870 2/20 0.40
USP2 O75604 1/20 0.40
CYP1A2 P05177 1/20 0.40
TSHR P16473 1/20 0.40
MAPK14 Q16539 2/20 0.39
MAPK10 P53779 1/20 0.39
HTR1D P28221 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HTR1E P28566 1/20 0.39
HTR7 P34969 1/20 0.39
HTR2B P41595 1/20 0.39
HTR6 P50406 1/20 0.39
MAPK11 Q15759 1/20 0.38
SOS1 Q07889 1/20 0.38
ABL1 P00519 1/20 0.38
SRC P12931 1/20 0.38
MKNK2 Q9HBH9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1271230 0.83 PIM1 (0.51) MKNK1MAPK14MAPK10MKNK2ALPL
SCHEMBL29617744 0.83 PIM1 (0.51) MKNK1MAPK14MAPK10MKNK2ALPL
SCHEMBL8742187 0.80 KMT2A (0.48) USP2CYP1A2KDM4E
SCHEMBL1593665 0.78 MKNK1 (0.42) MKNK1HTR1DHTR2AHTR2CHTR1E
SCHEMBL19352727 0.77 NUDT14 (0.44) PIM1
SCHEMBL1128927 0.74 RPS6KA5 (0.38) MKNK1RPS6KA5
SCHEMBL8318622 0.73 SRC (0.44) MKNK1CYP1A2MAPK14MAPK10HTR1D
SCHEMBL3715031 0.72 SRC (0.57) MKNK1CYP1A2MAPK14MAPK10ABL1
SCHEMBL28323720 0.72 RPS6KA5 (0.55) MKNK2RPS6KA5
SCHEMBL1921806 0.71 MKNK1 (0.47) MKNK1CSNK2A2CSNK2BMAPK14MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1482983-A4 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RES DEV CO (IL) 2006-07-12 EP claimed
EP-1482983-A2 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2004-12-08 EP claimed
WO-2003065971-A9 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RES DEV CO (IL) 2003-11-20 WO claimed
WO-2003065971-A2 NON-MYELOABLATIVE TOLEROGENIC TREATMENT WITH TYRPHOSTINS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2003-08-14 WO claimed