Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1271230 | 1.00 | PIM1 (0.51) | PIM1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL19352727 | 0.86 | NUDT14 (0.44) | PIM1NPC1RAB9A | |
| SCHEMBL6055040 | 0.83 | MKNK1 (0.41) | PIM1KDM4EMAPK10ALPLMKNK1 | |
| SCHEMBL8742187 | 0.79 | KMT2A (0.48) | ALDH1A1KDM4EGAAMAPTCDK2 | |
| SCHEMBL1592857 | 0.76 | ALDH1A1 (0.46) | PIM1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL14633242 | 0.76 | NPSR1 (0.63) | PIM1ALDH1A1KDM4EGAANPC1 | |
| SCHEMBL29930893 | 0.75 | GSK3B (0.58) | PIM1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL8723687 | 0.75 | MAPK1 (0.60) | PIM1ALDH1A1HSD17B10PIM3PIM2 | |
| SCHEMBL30931548 | 0.74 | ALDH1A1 (0.55) | PIM1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL1513056 | 0.74 | ALDH1A1 (0.55) | PIM1ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |