Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375600 | 0.86 | ALDH1A1 (0.35) | ALDH1A1KMT2ALMNAMAPK1SMN1; SMN2 | |
| SCHEMBL904362 | 0.78 | ALDH1A1 (0.40) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL6055317 | 0.75 | GAA (0.37) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL259737 | 0.73 | MMP2 (0.41) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL777187 | 0.70 | GAA (0.50) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL29367126 | 0.70 | GAA (0.50) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL143705 | 0.70 | GAA (0.50) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL14720743 | 0.69 | ALDH1A1 (0.43) | GAAALDH1A1MEN1KMT2AVDR | |
| Ammonia Solution, Strong SCHEMBL5917791 | 0.69 | GAA (0.48) | GAAALDH1A1MEN1KMT2AVDR | |
| SCHEMBL19949926 | 0.69 | GAA (0.48) | GAAALDH1A1MEN1KMT2AVDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450809-A4 | NUCLEOSIDES PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES | BIOCRYST PHARM INC (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050033051-A1 | Nucleosides preparation thereof and use as inhibitors of rna viral polymerases | BIOCRYST PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |
| EP-1450809-A2 | NUCLEOSIDES PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES | Biocryst Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003087298-A2 | NUCLEOSIDES PREPARATION THEREOF AND USE AS INHIBITORS OF RNA VIRAL POLYMERASES | BIOCRYST PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033051-A1 | Nucleosides preparation thereof and use as inhibitors of rna viral polymerases | NSUN2, RNASEH1, POLR2H | GAA 3374/4885ALDH1A1 3040/4885MEN1 3597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.