SCHEMBL6055879

SCHEMBL6055879

N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(NC(=O)C(F)(F)F)c1SC(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRP O00591 17/20 0.46
GABRD O14764 17/20 0.46
GABRA1 P14867 17/20 0.46
GABRB1 P18505 17/20 0.46
GABRG2 P18507 17/20 0.46
GABRB3 P28472 17/20 0.46
GABRA5 P31644 17/20 0.46
GABRA3 P34903 17/20 0.46
GABRA2 P47869 17/20 0.46
GABRB2 P47870 17/20 0.46
GABRA4 P48169 17/20 0.46
GABRE P78334 17/20 0.46
GABRA6 Q16445 17/20 0.46
GABRG1 Q8N1C3 17/20 0.46
GABRG3 Q99928 17/20 0.46
GABRQ Q9UN88 17/20 0.46
LMNA P02545 2/20 0.46
NR1I2 O75469 1/20 0.46
CYP3A4 P08684 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6055701 0.92 GABRP (0.45) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6055759 0.90 GABRB3 (0.46) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7714908 0.88 GABRB3 (0.45) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6055866 0.87 GABRB3 (0.44) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL4513950 0.87 GABRP (0.46) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL4521212 0.86 GABRB3 (0.43) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL9010480 0.85 GABRP (0.44) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6055742 0.85 GABRB3 (0.45) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6748566 0.85 GABRB3 (0.42) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL712966 0.84 GABRB3 (0.47) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060105969-A1 Anthelmintic compositions BRUCE CHRISTOPHER I 2006-05-18 US claimed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US claimed
EP-3324955-B1 COMPOSITION COMPRISING FIPRONIL AND DINOTEFURAN FOR USE IN AMETHOD OF CONTROLLING FLEAS IN NON HUMAN MAMMALS CEVA SANTE ANIMALE (FR) 2026-04-29 EP disclosed
US-11134685-B2 Compositions and uses thereof for controlling ectoparasites in non-human mammals Ceva Santé Animale (FR) 2021-10-05 US disclosed
US-20200163339-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Santé Animale (FR) 2020-05-28 US disclosed
US-20180213790-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Santé Animale (FR) 2018-08-02 US disclosed
EP-3259990-A1 METHODS FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Sante Animale (FR) 2017-12-27 EP disclosed
EP-3120846-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Sante Animale (FR) 2017-01-25 EP disclosed
US-20060105969-A1 Anthelmintic compositions BRUCE CHRISTOPHER I 2006-05-18 US disclosed
US-6372774-B1 THESE COMPOUNDS POSSESS ARTHROPODICIDAL, PLANT NEMATOCIDAL, ANTHELMINTIC AND ANTI-PROTOZOAL PROPERTIES RHONE-POULENC AGRICULTURE LTD. (GB) 2002-04-16 US disclosed
EP-0967206-A1 Derivatives of N-phenylpyrazoles RHONE POULENC AGRICULTURE LTD. (GB) 1999-12-29 EP disclosed
US-5916618-A PESTICIDE FOR MEDICATED FEEDSTUFF, DIETARY CONCENTRATE OR SUPPLEMENT RHONE-POULENC AGRICULTURE LTD. (GB) 1999-06-29 US disclosed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US disclosed
US-5608077-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS RHONE-POULENC AGRICULTURE LTD. (GB) 1997-03-04 US disclosed
US-5547974-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS RHONE-POULENC AGRICULTURE LTD. (GB) 1996-08-20 US disclosed
US-5232940-A Controlling insects, plant nematodes, helminths, protozoa BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) 1993-08-03 US disclosed
EP-0295117-A1 Derivatives of N-phenylpyrazoles RHONE-POULENC AGRICULTURE LIMITED (GB) 1988-12-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11134685-B2 Compositions and uses thereof for controlling ectoparasites in non-human mammals NISCH, NAMPT, TYR GABRP 2904/4885GABRD 3255/4885GABRA1 3400/4885
US-20060105969-A1 Anthelmintic compositions TUBB, TUBA3C, CYP51A1 GABRP 2567/4885GABRD 2908/4885GABRA1 3528/4885
US-20180213790-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS NISCH, NAMPT, TYR GABRP 2904/4885GABRD 3255/4885GABRA1 3400/4885
US-20200163339-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS NISCH, NAMPT, TYR GABRP 2904/4885GABRD 3255/4885GABRA1 3400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.