SCHEMBL6055890

SCHEMBL6055890

Nc1c(SC(F)(F)F)c(Br)nn1-c1c(Cl)cc(C(F)(F)F)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GABRA2 P47869 20/20 0.58
GABRB2 P47870 20/20 0.58
GABRP O00591 19/20 0.58
GABRD O14764 19/20 0.58
GABRA1 P14867 19/20 0.58
GABRB1 P18505 19/20 0.58
GABRG2 P18507 19/20 0.58
GABRB3 P28472 19/20 0.58
GABRA5 P31644 19/20 0.58
GABRA3 P34903 19/20 0.58
GABRA4 P48169 19/20 0.58
GABRE P78334 19/20 0.58
GABRA6 Q16445 19/20 0.58
GABRG1 Q8N1C3 19/20 0.58
GABRG3 Q99928 19/20 0.58
GABRQ Q9UN88 19/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6055926 0.87 GABRP (0.69) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL6055867 0.86 GABRP (0.56) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL6055871 0.85 GABRP (0.55) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL9489922 0.84 GABRP (0.57) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7711568 0.84 GABRA2 (0.55) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL7665209 0.82 GABRP (0.52) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL15406 0.81 GABRP (0.61) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL6055910 0.81 GABRP (0.51) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL3821756 0.80 GABRA2 (0.58) GABRA2GABRB2GABRPGABRDGABRA1
SCHEMBL3821846 0.80 GABRP (0.53) GABRA2GABRB2GABRPGABRDGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060105969-A1 Anthelmintic compositions BRUCE CHRISTOPHER I 2006-05-18 US claimed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US claimed
CN-1027341-C N-Phenylpyrazole Derivative Insecticides MAY & BAKER LTD (FR) 1995-01-11 CN claimed
EP-3324955-B1 COMPOSITION COMPRISING FIPRONIL AND DINOTEFURAN FOR USE IN AMETHOD OF CONTROLLING FLEAS IN NON HUMAN MAMMALS CEVA SANTE ANIMALE (FR) 2026-04-29 EP disclosed
US-11134685-B2 Compositions and uses thereof for controlling ectoparasites in non-human mammals Ceva Santé Animale (FR) 2021-10-05 US disclosed
US-20200163339-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Santé Animale (FR) 2020-05-28 US disclosed
US-20180213790-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Santé Animale (FR) 2018-08-02 US disclosed
EP-3324955-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAIN MAMMALS Ceva Sante Animale (FR) 2018-05-30 EP disclosed
EP-3259990-A1 METHODS FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Sante Animale (FR) 2017-12-27 EP disclosed
WO-2017017021-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAIN MAMMALS CEVA SANTE ANIMALE (FR) 2017-02-02 WO disclosed
EP-3120846-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS Ceva Sante Animale (FR) 2017-01-25 EP disclosed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US disclosed
US-5608077-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS RHONE-POULENC AGRICULTURE LTD. (GB) 1997-03-04 US disclosed
US-5547974-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS RHONE-POULENC AGRICULTURE LTD. (GB) 1996-08-20 US disclosed
EP-0418016-B1 N-phenylpyrazole derivatives as insecticides RHONE POULENC AGRICULTURE (GB) 1995-05-03 EP disclosed
CN-1027341-C N-Phenylpyrazole Derivative Insecticides MAY & BAKER LTD (FR) 1995-01-11 CN disclosed
US-5232940-A Controlling insects, plant nematodes, helminths, protozoa BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) 1993-08-03 US disclosed
EP-0418016-A1 N-phenylpyrazole derivatives as insecticides RHONE-POULENC AGRICULTURE LTD. (GB) 1991-03-20 EP disclosed
CN-88103601-A N-PHENYLPYRAZOLE DERIVATIVES 1988-12-28 CN disclosed
EP-0295117-A1 Derivatives of N-phenylpyrazoles RHONE-POULENC AGRICULTURE LIMITED (GB) 1988-12-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11134685-B2 Compositions and uses thereof for controlling ectoparasites in non-human mammals NISCH, NAMPT, TYR GABRA2 3449/4885GABRB2 3887/4885GABRP 2904/4885
US-20060105969-A1 Anthelmintic compositions TUBB, TUBA3C, CYP51A1 GABRA2 3701/4885GABRB2 2536/4885GABRP 2567/4885
US-20180213790-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS NISCH, NAMPT, TYR GABRA2 3449/4885GABRB2 3887/4885GABRP 2904/4885
US-20200163339-A1 COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS NISCH, NAMPT, TYR GABRA2 3449/4885GABRB2 3887/4885GABRP 2904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.