Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1023211 | 0.84 | BRD4 (0.42) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL4432777 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL27752958 | 0.82 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRALDH1A1MEN1MAPT | |
| SCHEMBL698490 | 0.81 | — | — | |
| SCHEMBL27104865 | 0.80 | ITGB3 (0.40) | ALDH1A1MAPTATM | |
| SCHEMBL27102500 | 0.80 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1ATM | |
| SCHEMBL11310192 | 0.79 | ALDH1A1 (0.47) | SMN1; SMN2TSHRALDH1A1EPHX2EPHX1 | |
| SCHEMBL4127454 | 0.79 | ALDH1A1 (0.47) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL14167163 | 0.79 | TSHR (0.52) | SMN1; SMN2TSHRALDH1A1MEN1MAPT | |
| SCHEMBL31463613 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615699-A2 | BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS | Merck & Co., Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092124-A2 | BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS | MERCK & CO., INC. (US) | 2004-10-28 | — | — | WO | disclosed |