Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | DAO | P14920 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118686 | 0.98 | FLT3 (0.71) | FLT3KDM4EHSD17B10MAPTDAO | |
| SCHEMBL29362757 | 0.98 | FLT3 (0.71) | FLT3KDM4EHSD17B10MAPTDAO | |
| Hydrochloric Acid SCHEMBL30071329 | 0.96 | FLT3 (0.69) | FLT3KDM4EHSD17B10MAPTDAO | |
| Hydrochloric Acid SCHEMBL20569802 | 0.96 | FLT3 (0.69) | FLT3KDM4EHSD17B10MAPTDAO | |
| Hydrochloric Acid SCHEMBL28280255 | 0.96 | FLT3 (0.69) | FLT3KDM4EHSD17B10MAPTDAO | |
| Hydrochloric Acid SCHEMBL16463892 | 0.96 | FLT3 (0.69) | FLT3KDM4EHSD17B10MAPTDAO | |
| Hydrochloric Acid SCHEMBL30164222 | 0.96 | FLT3 (0.69) | FLT3KDM4EHSD17B10MAPTDAO | |
| Water SCHEMBL30277651 | 0.96 | FLT3 (0.69) | FLT3KDM4EHSD17B10MAPTDAO | |
| Pyrrole SCHEMBL7648947 | 0.90 | KDM4E (0.61) | FLT3KDM4EHSD17B10MAPTDAO | |
| Isopropyl Alcohol SCHEMBL11540479 | 0.90 | FLT3 (0.61) | FLT3KDM4EHSD17B10MAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023077117-A1 | CRYSTALLINE FORMS OF N-((1R,3S)-3-(4-ACETYLPIPERAZIN-1-YL)CYCLOHEXYL)-4-FLUORO-7-METHYL-1H-INDOLE-2-CARBOXAMIDE | Epizyme, Inc. (US) | 2023-05-04 | — | — | WO | claimed |
| WO-2023077117-A1 | CRYSTALLINE FORMS OF N-((1R,3S)-3-(4-ACETYLPIPERAZIN-1-YL)CYCLOHEXYL)-4-FLUORO-7-METHYL-1H-INDOLE-2-CARBOXAMIDE | Epizyme, Inc. (US) | 2023-05-04 | — | — | WO | disclosed |
| EP-1648905-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | Abbott Laboratories (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005010009-A1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2005-02-03 | — | — | WO | disclosed |