⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29909710 | 1.00 | — | — | |
| SCHEMBL22896965 | 0.83 | GRM5 (0.35) | — | |
| SCHEMBL23887607 | 0.81 | SYK (0.42) | — | |
| SCHEMBL17601584 | 0.78 | LMNA (0.43) | — | |
| SCHEMBL1782191 | 0.77 | — | — | |
| SCHEMBL31205727 | 0.77 | — | — | |
| SCHEMBL1774897 | 0.77 | GAA (0.42) | — | |
| SCHEMBL1519145 | 0.77 | TLR8 (0.42) | — | |
| SCHEMBL21550282 | 0.75 | ESR1 (0.35) | — | |
| SCHEMBL20685774 | 0.75 | MAPK14 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 258 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361236-A9 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2025-11-27 | — | — | US | disclosed |
| US-12213978-B2 | Madrasin-derivative compounds, composition and uses thereof for treating cancer | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2025-02-04 | — | — | US | disclosed |
| CN-113226323-B | Ma Dexin derivative compounds, compositions and uses thereof for the treatment of cancer | 法国古士塔柏罗斯学院 | 2024-12-31 | — | — | CN | disclosed |
| US-20240400568-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2024-12-05 | — | — | US | disclosed |
| EP-4445902-A2 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | Carna Biosciences, Inc. (JP) | 2024-10-16 | — | — | EP | disclosed |
| EP-4081305-B1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | CARNA BIOSCIENCES INC (JP) | 2024-09-18 | — | — | EP | disclosed |
| US-12054490-B2 | Diacylglycerol kinase modulating compounds | GILEAD SCIENCES, INC. (US) | 2024-08-06 | — | — | US | disclosed |
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| US-20240182476-A1 | DIACYLGLYCEROL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2024-06-06 | — | — | US | disclosed |
| CN-115362003-B | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-03-22 | — | — | CN | disclosed |
| WO-2002066470-A1 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2002-08-29 | — | — | WO | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |
| CN-1037513-C | Pyrimidine compound and preparation method of medicinal salt thereof | MITSUI PETROCHEMICAL IND (JP) | 1998-02-25 | — | — | CN | disclosed |
| EP-0379806-B1 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL IND (JP) | 1996-04-10 | — | — | EP | disclosed |
| EP-0612746-A1 | Pyrimidines and their pharmaceutical acceptable salts and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
| CN-1090846-A | The preparation method of pyrimidines and its pharmaceutical salts | MITSUI PETROCHEMICAL IND (JP) | 1994-08-17 | — | — | CN | disclosed |
| US-5264435-A | Treatment of neurological diseases | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5147876-A | Nervous system disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| CN-1045390-A | Pyrimidine compound and preparation method and pharmaceutical use of pharmaceutical salt thereof | MITSUI PETROCHEMICAL IND (JP) | 1990-09-19 | — | — | CN | disclosed |
| EP-0379806-A2 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-01 | — | — | EP | disclosed |