Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.67 |
| ▸ | PDE6C | P51160 | 3/20 | 0.67 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872915 | 0.87 | PDE5A (0.58) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL5990273 | 0.86 | PDE5A (0.50) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL146830 | 0.85 | PDE5A (0.90) | PDE5APDE6C | |
| SCHEMBL29611957 | 0.85 | PDE5A (0.90) | PDE5APDE6C | |
| SCHEMBL2567278 | 0.82 | PDE5A (0.70) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL5085819 | 0.81 | PDE5A (0.65) | PDE5APDE6CALDH1A1MAPTHSD17B10 | |
| SCHEMBL5085823 | 0.81 | PDE5A (0.56) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL5964550 | 0.81 | PDE5A (0.70) | PDE5APDE6C | |
| SCHEMBL147337 | 0.80 | PDE5A (1.00) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL6367349 | 0.79 | PDE5A (0.84) | PDE5APDE6CPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153824-B2 | Inhibitors of phosphodiesterases in infertility | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-12-26 | — | — | US | disclosed |