Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.65 |
| ▸ | PDE6C | P51160 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872915 | 0.95 | PDE5A (0.58) | PDE5APDE6CALDH1A1MAPTMEN1 | |
| SCHEMBL7167750 | 0.92 | PDE5A (0.54) | PDE5APDE6CALDH1A1MAPTMEN1 | |
| SCHEMBL7019550 | 0.83 | PDE5A (0.46) | PDE5APDE6CKMT2AHSD17B10HDAC1 | |
| SCHEMBL6058528 | 0.81 | PDE5A (0.67) | PDE5APDE6CALDH1A1MAPTHSD17B10 | |
| SCHEMBL5085823 | 0.79 | PDE5A (0.56) | PDE5APDE6CALDH1A1MAPTMEN1 | |
| SCHEMBL147337 | 0.79 | PDE5A (1.00) | PDE5APDE6CALDH1A1MEN1KMT2A | |
| SCHEMBL2032429 | 0.77 | PDE5A (0.78) | PDE5APDE6CHDAC1HDAC6HDAC2 | |
| SCHEMBL6367349 | 0.76 | PDE5A (0.84) | PDE5APDE6CHDAC1HDAC6HDAC2 | |
| SCHEMBL3671938 | 0.75 | PDE5A (0.63) | PDE5APDE6CPDE3BPDE3A | |
| SCHEMBL15111105 | 0.74 | PDE5A (0.77) | PDE5APDE6CHDAC1HDAC6HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702555-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE | Pfizer Limited (GB) | 1996-03-27 | — | — | EP | claimed |
| WO-1994028902-A1 | PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF IMPOTENCE | PFIZER LIMITED (GB) | 1994-12-22 | — | — | WO | claimed |
| EP-1965863-A2 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF LUTS COMPRISING A PDE5 INHIBITOR AND A MUSCARINIC ANTAGONIST | Pfizer Products Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007072169-A2 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF LUTS COMPRISING A PDE5 INHIBITOR AND A MUSCARINIC ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |