Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 16/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.39 |
| ▸ | ESRRB | O95718 | 5/20 | 0.39 |
| ▸ | ESRRG | P62508 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PLD2 | O14939 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6704388 | 0.84 | ESR1 (0.47) | ESR1ESR2ESRRBESRRGKDM4E | |
| SCHEMBL6701790 | 0.69 | ESR1 (0.46) | ESR1ESR2ESRRGKDM4ECHRNB2 | |
| SCHEMBL2477011 | 0.69 | ESR1 (0.65) | ESR1ESR2ESRRBESRRGKDM4E | |
| SCHEMBL5523932 | 0.68 | ACHE (0.43) | ESR1ESR2ESRRBMEN1KMT2A | |
| SCHEMBL7624121 | 0.67 | ESR1 (0.47) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL185585 | 0.67 | HRH3 (0.70) | ESR1ESR2ESRRGKDM4EMEN1 | |
| SCHEMBL5525073 | 0.67 | ACHE (0.33) | ESR1ESRRG | |
| SCHEMBL8476224 | 0.66 | LTA4H (0.63) | ESR1ESR2ESRRBESRRGKDM4E | |
| SCHEMBL7538119 | 0.66 | ESR1 (0.55) | ESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL1477066 | 0.65 | KDM4E (0.69) | ESR1ESR2ESRRGKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877607-B1 | BIPHENYL COMPOUNDS AND USE THEREOF AS OESTROGENIC AGENTS | AVENTIS PHARMA SA (FR) | 2006-11-15 | — | — | EP | claimed |
| US-6563008-B2 | Treatment of disorders linked to hypofolliculinemia and of certain estrogen-dependent pathologies such as prostatic adenomas or carcinomas, and of benign tumours of the breast | AVENTIS PHARMA S.A. (FR) | 2003-05-13 | — | — | US | disclosed |