Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061077 | 0.86 | KDM4E (0.43) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL27913218 | 0.77 | TSHR (0.54) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL27653607 | 0.72 | TSHR (0.50) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL6061205 | 0.72 | TSHR (0.46) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL522404 | 0.71 | L3MBTL1 (0.47) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL27404312 | 0.71 | TSHR (0.52) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL6060652 | 0.69 | TSHR (0.47) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL523256 | 0.69 | TSHR (0.52) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL2805603 | 0.69 | ALDH1A1 (0.61) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 | |
| SCHEMBL8881493 | 0.68 | TSHR (0.48) | ALDH1A1CYP3A4TSHRTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |