Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168819 | 0.85 | KMT2A (0.53) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL10384205 | 0.81 | SLC6A2 (0.50) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL5844751 | 0.79 | KMT2A (0.47) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL6897382 | 0.79 | CES1 (0.49) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL11344345 | 0.78 | MAOB (0.47) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL11629530 | 0.78 | KMT2A (0.54) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL10941278 | 0.76 | PPARG (0.53) | KMT2ATDP1SLC6A2SLC6A3RAB9A | |
| SCHEMBL312995 | 0.76 | KMT2A (0.45) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL7038051 | 0.75 | LMNA (0.47) | KMT2ATDP1SLC6A2SLC6A3NPC1 | |
| SCHEMBL6880604 | 0.75 | CES1 (0.71) | KMT2ATDP1SLC6A2SLC6A3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697336-A2 | AROYLFURANES AND AROYLTHIOPHENES SUITABLE FOR THE TREATMENT OF CANCER | Basilea Pharmaceutica AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061476-A2 | AROYLFURANES AND AROYLTHIOPHENES | BASILEA PHARMACEUTICA AG (CH) | 2005-07-07 | — | — | WO | disclosed |