Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061410 | 0.94 | POLB (0.48) | POLBMEN1KMT2AEGFRCYP1A1 | |
| SCHEMBL6061323 | 0.84 | MEN1 (0.42) | POLBMEN1KMT2AEGFRCYP1A1 | |
| SCHEMBL6061070 | 0.83 | EGFR (0.43) | POLBMEN1KMT2AEGFRCYP1A2 | |
| SCHEMBL6061241 | 0.83 | EGFR (0.43) | POLBMEN1KMT2AEGFRCYP1A2 | |
| SCHEMBL6061244 | 0.83 | EGFR (0.43) | POLBMEN1KMT2AEGFRCYP1A2 | |
| SCHEMBL6061061 | 0.81 | MAPT (0.39) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6314520 | 0.80 | LMNA (0.43) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL6752458 | 0.80 | LMNA (0.43) | MEN1KMT2ASMN1; SMN2GAAMAPT | |
| SCHEMBL6061011 | 0.80 | GAA (0.60) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL6061043 | 0.79 | CYP1A1 (0.55) | POLBMEN1KMT2ACYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482953-A4 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS INC (US) | 2006-12-13 | — | — | EP | claimed |
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | PHAN HIEU T (CH) | 2005-06-09 | — | — | US | claimed |
| EP-1482953-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| WO-2003068240-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS, INC. (US) | 2003-08-21 | — | — | WO | claimed |
| EP-1482953-A4 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS INC (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | PHAN HIEU T (CH) | 2005-06-09 | — | — | US | disclosed |
| EP-1482953-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003068240-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | APOB, APOL1, LDLR | POLB 1364/4885MEN1 4155/4885KMT2A 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.