Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.62 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757427 | 0.85 | CASP3 (0.44) | PIN1PIN4ALDH1A1MAPTHSD17B10 | |
| SCHEMBL7549529 | 0.81 | CA12 (0.60) | ALDH1A1MAPTHSD17B10CYP1A2KMT2A | |
| SCHEMBL523639 | 0.81 | PIN1 (0.68) | PIN1PIN4ALDH1A1MAPTHTT | |
| SCHEMBL5998379 | 0.81 | PIN1 (0.41) | PIN1PIN4ALDH1A1CASP3KMT2A | |
| SCHEMBL11453331 | 0.80 | ALDH1A1 (0.77) | PIN1PIN4ALDH1A1MAPTHTT | |
| SCHEMBL18485415 | 0.80 | KDM4E (0.45) | ALDH1A1MAPTHSD17B10KMT2ATNF | |
| SCHEMBL12235635 | 0.79 | CYP1B1 (0.53) | ALDH1A1MAPTHSD17B10NPSR1CYP1A2 | |
| SCHEMBL442751 | 0.77 | PIN1 (1.00) | PIN1PIN4ALDH1A1MAPTHTT | |
| SCHEMBL11395567 | 0.77 | PIN1 (0.75) | PIN1PIN4ALDH1A1MAPTHTT | |
| SCHEMBL25175089 | 0.76 | PIN1 (0.61) | PIN1PIN4ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2004108681-A1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENOUS ERYTHROPOIETIN | FIBROGEN, INC. (US) | 2004-12-16 | — | — | WO | disclosed |