Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.50 |
| ▸ | CTSL | P07711 | 9/20 | 0.47 |
| ▸ | CTSB | P07858 | 8/20 | 0.47 |
| ▸ | CTSH | P09668 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6061604 | 1.00 | CTSK (0.50) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6683526 | 0.80 | CTSK (0.53) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6683529 | 0.80 | CTSK (0.53) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6696441 | 0.79 | CTSK (0.46) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6063058 | 0.79 | CTSL (0.51) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6062157 | 0.79 | CTSL (0.54) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6062159 | 0.79 | CTSL (0.54) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6653241 | 0.79 | CTSK (0.46) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6063052 | 0.79 | CTSL (0.51) | CTSKCTSLCTSBCTSHCTSS | |
| SCHEMBL6694050 | 0.79 | CTSK (0.49) | CTSKCTSLCTSBCTSHCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |