SCHEMBL6062174

SCHEMBL6062174

Cc1cccc([CH][SiH3])c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.42
ATM Q13315 1/20 0.42
ALDH1A1 P00352 6/20 0.41
TSHR P16473 3/20 0.41
CYP2A6 P11509 2/20 0.38
CYP1A2 P05177 1/20 0.38
ACHE P22303 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
ADRB1 P08588 1/20 0.35
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33
GAA P10253 1/20 0.33
HPGD P15428 1/20 0.33
MAPT P10636 2/20 0.32
RAPGEF4 Q8WZA2 1/20 0.32
CD44 P16070 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31146794 0.81 TRPA1 (0.39) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL6546426 0.79 TRPA1 (0.46) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL4318496 0.79 TRPA1 (0.46) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL3306781 0.79 TRPA1 (0.46) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL1609965 0.77 TRPA1 (0.44) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL17220278 0.75 TRPA1 (0.42) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL28496 0.75 TRPA1 (0.42) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL1509713 0.75 TRPA1 (0.42) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL29444 0.75 TSHR (0.65) TRPA1ATMALDH1A1TSHRCYP2A6
SCHEMBL6631634 0.75 TRPA1 (0.48) TRPA1ATMALDH1A1TSHRCYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458061-B1 Agent for preserving wood and wooden materials DESOWAG MATERIALSCHUTZ GMBH (DE) 1995-10-11 EP claimed
EP-0458060-B1 Agent for preserving wood and wooden materials DESOWAG MATERIALSCHUTZ GMBH (DE) 1995-10-11 EP claimed
EP-0963996-B9 Transition metal compound, catalyst component and catalyst for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORP (JP) 2006-09-06 EP disclosed
EP-0963996-B1 Transition metal compound, catalyst component and catalyst for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORP (JP) 2006-05-24 EP disclosed
US-6509426-B2 Dichloro(1,1'-dimethylsilylenebis(2-methyl-4-(4-methoxyphenyl) -4H-azulenyl))zirconium, for example; can produce polyolefin with high molecular weight and high melting point for extrusion or injection moldability JAPAN POLYCHEM CORPORATION (JP) 2003-01-21 US disclosed
US-20010023296-A1 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer JAPAN POLYCHEM CORPORATION (JP) 2001-09-20 US disclosed
US-6218558-B1 BRIDGED OXYGEN-, NITROGEN- OR SULFUR-CONTAINING METALLOCENE CATALYST CONTAINING AT LEAST CYCLOPENTADIENE RING FUSED TO A C7-10 RING JAPAN POLYCHEM CORPORATION (JP) 2001-04-17 US disclosed
EP-0963996-A2 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer Japan Polychem Corporation (JP) 1999-12-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010023296-A1 Novel transition metal compound, catalyst component for olefin polymerization and process for the preparation of alpha-olefin polymer OSTC, TCP1, COG1 TRPA1 1938/4885ATM 2834/4885ALDH1A1 605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.