Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262549 | 0.94 | OPRM1 (0.36) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3026785 | 0.87 | OPRM1 (0.40) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5280131 | 0.81 | OPRM1 (0.41) | KCNH2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5820159 | 0.79 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1GAA | |
| SCHEMBL6988066 | 0.78 | — | — | |
| SCHEMBL7567388 | 0.76 | HSD17B10 (0.37) | OPRM1OPRD1OPRK1OPRL1HSD17B10 | |
| SCHEMBL26547308 | 0.75 | LMNA (0.41) | CYP2D6HSD17B10TSHR | |
| SCHEMBL5169885 | 0.74 | — | — | |
| SCHEMBL16295698 | 0.74 | — | — | |
| Acetic Acid SCHEMBL21640297 | 0.73 | HSD17B10 (0.41) | OPRM1OPRD1OPRK1OPRL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694357-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058348-A1 | USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-30 | — | — | WO | disclosed |