SCHEMBL6062849

SCHEMBL6062849

CS(=O)(=O)CCCN(C(=O)c1nc2ccccc2o1)C(=O)C(CS(=O)(=O)Cc1ccccc1)NC(=O)N1CCOCC1

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSS P25774 12/20 0.42
CTSL P07711 4/20 0.35
CTSB P07858 4/20 0.35
CTSK P43235 2/20 0.34
KDM4E B2RXH2 1/20 0.34
CTSH P09668 1/20 0.34
CTSC P53634 1/20 0.34
FAAH O00519 1/20 0.34
CES1 P23141 1/20 0.34
DAGLA Q9Y4D2 1/20 0.34
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6461829 0.93 CTSS (0.43) CTSSCTSLCTSBCTSKKDM4E
SCHEMBL6463182 0.92 CTSS (0.43) CTSSCTSLCTSBCTSKKDM4E
SCHEMBL7043169 0.91 CTSS (0.44) CTSSCTSLCTSBCTSKKDM4E
SCHEMBL7114795 0.89 LMNA (0.35) CTSSKDM4EALDH1A1
SCHEMBL6464590 0.87 CTSS (0.35) CTSSKDM4EALDH1A1
SCHEMBL6462678 0.86 CTSS (0.40) CTSSCTSLCTSBCTSKKDM4E
SCHEMBL7046391 0.86 FAAH (0.37) CTSSKDM4EFAAHCES1DAGLA
SCHEMBL7045520 0.85 FAAH (0.36) CTSSCTSKFAAHCES1DAGLA
SCHEMBL6468761 0.85 CTSS (0.40) CTSSCTSLCTSBCTSKCTSH
SCHEMBL7044830 0.85 CTSS (0.40) CTSSCTSLCTSBCTSKCTSH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
US-6576630-B1 Alkanoyl substituted benzooxazoles or naphthooxazoles AXYS PHARMACEUTICALS, INC. 2003-06-10 US disclosed