SCHEMBL6063574

SCHEMBL6063574

[CH2]COC(=O)c1ccc(C(C)(C)C)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.49
CA2 P00918 2/20 0.49
MAPT P10636 3/20 0.49
TDP1 Q9NUW8 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HDAC1 Q13547 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
MAPK1 P28482 2/20 0.47
ALDH1A1 P00352 2/20 0.47
LMNA P02545 1/20 0.47
ALOX15 P16050 1/20 0.47
APEX1 P27695 1/20 0.47
RECQL P46063 1/20 0.47
HSD17B10 Q99714 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
SRD5A2 P31213 1/20 0.47
TNF P01375 1/20 0.46
KLF5 Q13887 1/20 0.46
NOD1 Q9Y239 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6647729 0.86 LMNA (0.43) CA1CA2MAPTTDP1MAPK1
SCHEMBL5456918 0.85 HDAC1 (0.52) CA1CA2MAPTTDP1L3MBTL1
SCHEMBL571045 0.83 CA12 (0.63) CA1CA2MAPTTDP1NPSR1
SCHEMBL7635028 0.82 CA1 (0.47) CA1CA2MAPTTDP1L3MBTL1
SCHEMBL6896519 0.81 CA1 (0.53) CA1CA2MAPTTDP1L3MBTL1
SCHEMBL18477456 0.81 CA1 (0.49) CA1CA2MAPTTDP1L3MBTL1
SCHEMBL14984037 0.81 TDP1 (0.58) CA1CA2MAPTTDP1L3MBTL1
SCHEMBL2334169 0.81 CA1 (0.49) CA1CA2MAPTTDP1L3MBTL1
SCHEMBL10980639 0.81 CES2 (0.53) MAPTMAPK1ALDH1A1LMNANPC1
SCHEMBL9419972 0.81 SNCA (0.54) CA1CA2MAPTTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060233973-A1 Cellulose ester film, manufacturing method thereof, optical film, polarizing plate and liquid crystal display KONICA MINOLTA OPTO, INC. 2006-10-19 US disclosed
US-5025048-A Oxygen resistant, storage-stable curable polysiloxanes hydrosilated by a polycyclic polyene and a compound containing an amine and a hydroxy, both sterically hindered HERCULES INCORPORATED (US) 1991-06-18 US disclosed
US-4551467-A Vasodilating cyanoalkyl esters of 1,4-dihydropyridines BAYER AKTIENGESELLSCHAFT (DE) 1985-11-05 US disclosed
US-4226999-A ANTIOXIDANTS FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1980-10-07 US disclosed
US-4202816-A ENOL-PIPERIDINE METAL COMPLEXES CIBA-GEIGY CORPORATION (US) 1980-05-13 US disclosed
US-4198334-A HEAT, LIGHT, OXIDATION RESISTANCE, PLASTICS CIBA-GEIGY CORPORATION (US) 1980-04-15 US disclosed
US-4148784-A HEAT, LIGHT AND OXIDATION RESISTANCE FOR SYNTHETIC POLYMERS CIBA-GEIGY CORPORATION (US) 1979-04-10 US disclosed
US-4061616-A PHOTO- AND THERMAL DEGRADATION, OCTAMETHYL-4,4'-DIHYDROXY-BIPIPERIDYLS SANKYO COMPANY LIMITED (JA) 1977-12-06 US disclosed
US-4007158-A 9-AZA- 1,5-DIOXA-SPIRO (5,5) UNDECANES SANKYO COMPANY LIMITED (JA) 1977-02-08 US disclosed