SCHEMBL6063984

SCHEMBL6063984

CC1=C(C)c2c(cccc2-c2ccccc2)[C]1[SiH2][C]1C(C)=C(C)c2c1cccc2-c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.39
CD274 Q9NZQ7 1/20 0.39
HNF4A P41235 1/20 0.35
ALDH1A1 P00352 3/20 0.34
HSD17B10 Q99714 2/20 0.34
CYP2A6 P11509 2/20 0.34
HPGD P15428 1/20 0.34
BCL2L1 Q07817 1/20 0.34
MAPK1 P28482 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
CYP2B6 P20813 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAOB P27338 1/20 0.33
PTGS2 P35354 1/20 0.32
AKT1 P31749 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7105740 0.92 PDCD1 (0.34) PDCD1CD274HNF4AALDH1A1CYP2A6
SCHEMBL6234169 0.81 PDCD1 (0.38) PDCD1CD274HNF4ADPP4SCN8A
SCHEMBL6234914 0.80 HDAC4 (0.44) ALDH1A1HSD17B10CYP2A6HPGDHDAC4
SCHEMBL6237068 0.77 DHFR (0.41) ALDH1A1CYP2A6HPGDMAOBENPP1
SCHEMBL6235606 0.75 CDC25A (0.35) ALDH1A1
SCHEMBL4621848 0.72 CDC25A (0.38) ALDH1A1HPGDSMN1; SMN2
SCHEMBL7030691 0.72 GABRA1 (0.38) PDCD1CD274DPP4DRD2
SCHEMBL7107949 0.72 MAPT (0.37) PDCD1CD274ALDH1A1MEN1KMT2A
SCHEMBL7105080 0.72 CA2 (0.38) ALDH1A1
SCHEMBL7030684 0.72 GABRA1 (0.38) HPGDDPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001053356-A1 CATALYST SYSTEM WITH A SELECTED TRANSITION METAL: COCATALYST RATIO BASELL POLYOLEFINE GMBH (DE) 2001-07-26 WO claimed
WO-2023085817-A1 METALLOCENE COMPOUND FOR POLYMERIZATION OF ULTRA-HIGH MOLECULAR WEIGHT POLYOLEFIN, AND METHOD FOR PREPARING ULTRA-HIGH MOLECULAR WEIGHT POLYOLEFIN POLYMER USING SAME 주식회사 에스피씨아이 2023-05-19 WO disclosed
EP-2824107-B1 ANSA-METALLOCENE COMPOUND AND METHOD FOR PREPARING SUPPORTED CATALYST USING SAME LG CHEMICAL LTD (KR) 2017-01-18 EP disclosed
EP-2824107-A1 ANSA-METALLOCENE COMPOUND AND METHOD FOR PREPARING SUPPORTED CATALYST USING SAME LG CHEM, LTD. (KR) 2015-01-14 EP disclosed
US-7005400-B2 Component of catalyst for polymerizing olefin, catalyst for polymerizing olefin and process for polymerizing olefin JAPAN POLYCHEM CORPORATION (JP) 2006-02-28 US disclosed
EP-0832924-B1 Polyolefin composition for the preparation of non-wovens BASELL POLYOLEFINE GMBH (DE) 2004-10-13 EP disclosed
EP-0889059-B1 Catalyst based on monoazadiene metal complexes BAYER AG (DE) 2003-02-12 EP disclosed
EP-1268657-A1 METHOD OF PREPARATION OF CROSSLINKED BLENDS OF AMORPHOUS AND CRYSTALLINE POLYMERS EXXON CHEMICAL PATENTS INC. (US) 2003-01-02 EP disclosed
EP-1238008-A1 CROSSLINKED BLENDS OF AMORPHOUS AND CRYSTALLINE POLYMERS AND THEIR APPLICATIONS EXXON CHEMICAL PATENTS INC. (US) 2002-09-11 EP disclosed
EP-1219657-A1 POLYARYLENE AND METHOD FOR PRODUCTION THEREOF Japan Science and Technology Corporation (JP) 2002-07-03 EP disclosed
US-20020052446-A1 Composition based on monofluorometal complexes BAYER AKTIENGESELLSCHAFT (DE) 2002-05-02 US disclosed
US-6323284-B1 COMBINING ALPHA.-OLEFIN MONOMER CONTAINING 3 OR MORE CARBON ATOMS AND DIOLEFIN MONOMER IN THE PRESENCE OF NON-STEREOSPECIFIC AND STEREOSPECIFIC METALLOCENE CATALYST SYSTEMS TO FORM POLYMER EXXONMOBIL CHEMICAL PATENTS, INC. 2001-11-27 US disclosed
WO-2001042351-A1 METHOD OF PREPARATION OF CROSSLINKED BLENDS OF AMORPHOUS AND CRYSTALLINE POLYMERS EXXON CHEMICAL PATENTS INC. (US) 2001-06-14 WO disclosed
WO-2001042350-A1 CROSSLINKED BLENDS OF AMORPHOUS AND CRYSTALLINE POLYMERS AND THEIR APPLICATIONS EXXON CHEMICAL PATENTS INC. (US) 2001-06-14 WO disclosed
US-5965678-A Catalyst system based on monoazadiene metal complexes BAYER AG (DE) 1999-10-12 US disclosed
EP-0889059-A1 Catalyst based on monoazadiene metal complexes BAYER AG (DE) 1999-01-07 EP disclosed
EP-0832924-A2 Polyolefin composition for the preparation of non-wovens TARGOR GmbH (DE) 1998-04-01 EP disclosed