Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7775633 | 0.85 | KDM4E (0.57) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL6312480 | 0.80 | HTR1A (0.62) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8648451 | 0.78 | HTR1A (0.55) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8647825 | 0.77 | HTR1A (0.54) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL10753828 | 0.77 | IGF1R (0.63) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL7474354 | 0.77 | HTR1A (1.00) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8010247 | 0.77 | HTR1A (1.00) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL7474356 | 0.77 | HTR1A (1.00) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8646293 | 0.77 | HTR1A (0.53) | HTR1AMEN1KMT2AADRA1ADRD4 | |
| SCHEMBL8648288 | 0.77 | HTR1A (0.54) | HTR1AMEN1KMT2AADRA1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706147-A2 | COMBINATION THERAPY WITH 5-HT sb 1A /sb AND 5-HT sb 1B /sb RECEPTOR ANTAGONISTS | Recordati Ireland Limited (IE) | 2006-10-04 | — | — | EP | claimed |
| WO-2005070460-A2 | COMBINATION THERAPY WITH 5-HT1A AND 5-HT1B RECEPTOR ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2005-08-04 | — | — | WO | claimed |