Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 10/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065376 | 0.92 | PKM (0.41) | PKMPPARDPPARAAGERPOLB | |
| SCHEMBL6065143 | 0.92 | PKM (0.42) | PKMPPARDPOLBMAPTFFAR1 | |
| SCHEMBL6065379 | 0.91 | PKM (0.40) | PKMPPARDPPARAAGERPOLB | |
| SCHEMBL6064615 | 0.90 | PPARD (0.45) | PPARDPPARAPPARG | |
| SCHEMBL6065369 | 0.90 | PKM (0.40) | PKMPPARDPPARAPOLBMAPT | |
| SCHEMBL6065741 | 0.90 | PKM (0.40) | PKMFFAR1SCN9A | |
| SCHEMBL6064601 | 0.87 | PKM (0.43) | PKMPOLBMAPTFFAR1SCN9A | |
| SCHEMBL6065163 | 0.85 | PKM (0.41) | PKMPPARDPPARAMAOBPPARG | |
| SCHEMBL6065368 | 0.84 | PKM (0.41) | PKMPOLBMAPTSCN9A | |
| SCHEMBL6017372 | 0.84 | PKM (0.43) | PKMPPARDPPARAMAOBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |