Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065379 | 0.96 | PKM (0.40) | PKMAGERMAPTMEN1ALDH1A1 | |
| SCHEMBL6065368 | 0.92 | PKM (0.41) | PKMMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL6064609 | 0.92 | PKM (0.42) | PKMAGERMAPTPPARAPPARG | |
| SCHEMBL6064614 | 0.90 | PPARD (0.40) | AGERPPARAPPARGTRPV1PPARD | |
| SCHEMBL6065718 | 0.88 | PKM (0.40) | PKMMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL6064761 | 0.86 | AGER (0.40) | AGERPPARAPPARGTRPV1HCRTR2 | |
| SCHEMBL6065143 | 0.84 | PKM (0.42) | PKMMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL6064612 | 0.84 | KDM4E (0.47) | AGERALDH1A1LMNAPPARAPPARG | |
| SCHEMBL6065369 | 0.84 | PKM (0.40) | PKMMAPTMEN1LMNAKMT2A | |
| SCHEMBL6065284 | 0.82 | PKM (0.39) | PKMMAPTMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |