Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 8/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | GOT1 | P17174 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065408 | 0.92 | PPARD (0.40) | GCGRTRPV1KDM4EPPARGPPARD | |
| SCHEMBL6065284 | 0.90 | PKM (0.39) | GCGRTRPV1GOT1BACE1 | |
| SCHEMBL6065359 | 0.89 | KDM4E (0.38) | GCGRTRPV1KDM4ECDK2PPARG | |
| SCHEMBL6065370 | 0.85 | PPARD (0.39) | GCGRTRPV1KDM4ECDK2PPARG | |
| SCHEMBL6065360 | 0.84 | PPARD (0.44) | KDM4EPPARGPPARDPPARA | |
| SCHEMBL6065162 | 0.82 | PKM (0.40) | GCGRTRPV1PPARD | |
| SCHEMBL6064607 | 0.82 | PPARD (0.41) | GCGRTRPV1KDM4EPPARGPPARD | |
| SCHEMBL6064622 | 0.80 | PPARD (0.38) | GCGRTRPV1KDM4ECDK2PPARG | |
| SCHEMBL6064614 | 0.80 | PPARD (0.40) | TRPV1KDM4EPPARGPPARDPPARA | |
| SCHEMBL6065368 | 0.79 | PKM (0.41) | TRPV1GOT1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |