Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 5/20 | 0.40 |
| ▸ | GCGR | P47871 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6064773 | 0.92 | GCGR (0.38) | PPARDGCGRKDM4EPPARAPPARG | |
| SCHEMBL6065360 | 0.92 | PPARD (0.44) | PPARDKDM4EPPARAPPARG | |
| SCHEMBL6065162 | 0.90 | PKM (0.40) | PPARDGCGRTRPV1ALDH1A1LMNA | |
| SCHEMBL6064607 | 0.88 | PPARD (0.41) | PPARDGCGRKDM4EPPARAPPARG | |
| SCHEMBL6064622 | 0.87 | PPARD (0.38) | PPARDGCGRKDM4EPPARAPPARG | |
| SCHEMBL6065385 | 0.83 | PPARD (0.44) | PPARDKDM4EPPARAPPARG | |
| SCHEMBL6065284 | 0.82 | PKM (0.39) | GCGRTRPV1ALDH1A1LMNACYP2C9 | |
| SCHEMBL6065359 | 0.82 | KDM4E (0.38) | PPARDGCGRKDM4EPPARAPPARG | |
| SCHEMBL6065369 | 0.82 | PKM (0.40) | PPARDPPARAPPARGLMNATSHR | |
| SCHEMBL6065278 | 0.81 | KDM4E (0.48) | PPARDKDM4EPPARAPPARGTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |