Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 17/20 | 0.44 |
| ▸ | PPARA | Q07869 | 11/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065408 | 0.92 | PPARD (0.40) | PPARDPPARAPPARGKDM4E | |
| SCHEMBL6065385 | 0.92 | PPARD (0.44) | PPARDPPARAPPARGPTGDR2KDM4E | |
| SCHEMBL6065369 | 0.90 | PKM (0.40) | PPARDPPARAPPARG | |
| SCHEMBL6064615 | 0.88 | PPARD (0.45) | PPARDPPARAPPARGPTGDR2KDM4E | |
| SCHEMBL6064773 | 0.84 | GCGR (0.38) | PPARDPPARAPPARGKDM4E | |
| SCHEMBL6064764 | 0.82 | PPARD (0.36) | PPARDPPARAPPARG | |
| SCHEMBL6064614 | 0.82 | PPARD (0.40) | PPARDPPARAPPARGKDM4E | |
| SCHEMBL6065162 | 0.82 | PKM (0.40) | PPARD | |
| SCHEMBL6064761 | 0.81 | AGER (0.40) | PPARDPPARAPPARGKDM4E | |
| SCHEMBL6064607 | 0.80 | PPARD (0.41) | PPARDPPARAPPARGPTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725546-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085235-A1 | PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |