Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6065007 | 0.71 | AR (0.37) | PRKCZGAARAB9AMAPTALDH1A1 | |
| SCHEMBL4370222 | 0.71 | AR (0.39) | PRKCZMAPTALDH1A1ARHPGD | |
| SCHEMBL4374929 | 0.67 | MAPT (0.39) | PRKCZGAARAB9AMAPTALDH1A1 | |
| SCHEMBL4381278 | 0.67 | AR (0.39) | PRKCZGAARAB9AMAPTALDH1A1 | |
| SCHEMBL4386448 | 0.67 | AR (0.40) | PRKCZGAARAB9AMAPTALDH1A1 | |
| SCHEMBL13863268 | 0.66 | AR (0.41) | PRKCZMAPTALDH1A1ARHPGD | |
| SCHEMBL4370270 | 0.66 | GRIA4 (0.44) | PRKCZMAPTALDH1A1ARHPGD | |
| SCHEMBL24208929 | 0.65 | MAPT (0.62) | PRKCZGAARAB9AMAPTAR | |
| SCHEMBL7463777 | 0.64 | ALDH1A1 (0.41) | MAPTALDH1A1MAPK1HPGD | |
| SCHEMBL7468472 | 0.62 | PTGS2 (0.51) | MAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |