Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18886122 | 0.83 | GRIK1 (0.51) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL4427296 | 0.81 | GRM8 (0.42) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL6378815 | 0.78 | GRIK1 (0.52) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7344592 | 0.77 | SLC1A5 (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL7344594 | 0.77 | SLC1A5 (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL30963029 | 0.77 | SLC1A5 (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL20425536 | 0.77 | SLC1A5 (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL30861851 | 0.77 | SLC1A5 (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL31369826 | 0.75 | GRIA2 (0.59) | GRIK1GRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL31370062 | 0.75 | MAOA (0.55) | GRIK1GRIA2GRIA1GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635816-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Nicox S.A. (FR) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004110432-A1 | ENALAPRIL-NITROXYDERIVATIVES DERIVATIVES AND RELATED COMPOUNDS AS ACE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | NICOX S.A. (FR) | 2004-12-23 | — | — | WO | disclosed |