SCHEMBL7344592

SCHEMBL7344592

N[C@@H](CCc1cccc(Cl)c1)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A5 Q15758 1/20 0.55
KIF11 P52732 3/20 0.53
TAAR1 Q96RJ0 2/20 0.51
GRIK1 P39086 2/20 0.51
GRIK2 Q13002 2/20 0.51
IDO1 P14902 1/20 0.51
TDO2 P48775 1/20 0.51
GRIA1 P42261 1/20 0.51
GRIA2 P42262 1/20 0.51
GRIA3 P42263 1/20 0.51
GRIA4 P48058 1/20 0.51
GRIK3 Q13003 1/20 0.51
KMT2A Q03164 3/20 0.49
ALDH1A1 P00352 3/20 0.49
MEN1 O00255 1/20 0.49
HPGD P15428 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HTR3E A5X5Y0 1/20 0.49
HTR3B O95264 1/20 0.49
HTR3A P46098 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7344594 1.00 SLC1A5 (0.55) SLC1A5KIF11TAAR1GRIK1GRIK2
SCHEMBL30861851 1.00 SLC1A5 (0.55) SLC1A5KIF11TAAR1GRIK1GRIK2
SCHEMBL30963029 1.00 SLC1A5 (0.55) SLC1A5KIF11TAAR1GRIK1GRIK2
SCHEMBL20425536 1.00 SLC1A5 (0.55) SLC1A5KIF11TAAR1GRIK1GRIK2
SCHEMBL16542492 0.91 GRIK1 (0.52) SLC1A5KIF11TAAR1GRIK1IDO1
SCHEMBL430509 0.91 GRIK1 (0.52) SLC1A5KIF11TAAR1GRIK1IDO1
SCHEMBL23818056 0.84 SLC1A5 (0.46) SLC1A5KIF11IDO1TDO2GRIA2
SCHEMBL18886122 0.84 GRIK1 (0.51) KIF11GRIK1GRIK2GRIA1GRIA2
SCHEMBL42994 0.83 SLC7A5 (0.65) KIF11GRIA2PNMTALPIPKM
SCHEMBL298829 0.83 SLC7A5 (0.65) KIF11GRIA2PNMTALPIPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3628680-A1 MODULATION OF COMPLEMENT ACTIVITY RA Pharmaceuticals, Inc. (US) 2020-04-01 EP claimed
US-10435438-B2 Modulation of complement activity RA PHARMACEUTICALS, INC. (US) 2019-10-08 US claimed
US-20190119328-A1 MODULATION OF COMPLEMENT ACTIVITY UCB HOLDINGS, INC. 2019-04-25 US claimed
US-20170137468-A1 MODULATION OF COMPLEMENT ACTIVITY UCB HOLDINGS, INC. 2017-05-18 US claimed
EP-3154561-A2 MODULATION OF COMPLEMENT ACTIVITY RA Pharmaceuticals, Inc. (US) 2017-04-19 EP claimed
WO-2015191951-A2 MODULATION OF COMPLEMENT ACTIVITY RA PHARMACEUTICALS, INC. (US) 2015-12-17 WO claimed
US-20260116923-A1 CYCLIC PEPTIDE IL-1BETA TRAP FOR THE TREATMENT OF ATHEROSCLEROSIS AND INFLAMMATORY DISORDERS MERCK SHARP & DOHME LLC (US) 2026-04-30 US disclosed
EP-4729094-A2 Modulators of complement activity UCB Holdings, Inc. (US) 2026-04-22 EP disclosed
US-12558398-B2 Inflammatory disease treatment with complement inhibitors UCB HOLDINGS, INC. (US) 2026-02-24 US disclosed
EP-4218790-B1 MODULATORS OF COMPLEMENT ACTIVITY UCB HOLDINGS INC (US) 2026-02-18 EP disclosed
US-20250090624-A1 MODULATORS OF COMPLEMENT ACTIVITY UCB HOLDINGS, INC. 2025-03-20 US disclosed
US-12239684-B2 Modulators of complement activity RA PHARMACEUTICALS, INC. (US) 2025-03-04 US disclosed
EP-4028126-B1 TREATMENT OF A NEUROLOGICAL DISEASE WITH COMPLEMENT INHIBITORS RA PHARMACEUTICALS INC (US) 2025-02-26 EP disclosed
US-20170137468-A1 MODULATION OF COMPLEMENT ACTIVITY UCB HOLDINGS, INC. 2017-05-18 US disclosed
WO-2016123371-A1 MODULATORS OF COMPLEMENT ACTIVITY RA PHARMACEUTICALS, INC. (US) 2016-08-04 WO disclosed
US-20160024159-A1 POTENT AND SELECTIVE INHIBITORS OF NAV1.7 AMGEN INC. (US) 2016-01-28 US disclosed
EP-0938477-A4 BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS CEPHALON INC (US) 1999-12-29 EP disclosed
US-5952328-A MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES CEPHALON, INC. (US) 1999-09-14 US disclosed
EP-0938477-A1 BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS CEPHALON, INC. (US) 1999-09-01 EP disclosed
WO-1998021186-A1 BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS CEPHALON, INC. (US) 1998-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190119328-A1 MODULATION OF COMPLEMENT ACTIVITY C5, C3AR1, CFH SLC1A5 4225/4885KIF11 4739/4885TAAR1 4241/4885
US-20170137468-A1 MODULATION OF COMPLEMENT ACTIVITY C5, C3AR1, CFH SLC1A5 4225/4885KIF11 4739/4885TAAR1 4241/4885
US-20260116923-A1 CYCLIC PEPTIDE IL-1BETA TRAP FOR THE TREATMENT OF ATHEROSCLEROSIS AND INFLAMMATORY DISORDERS IL1A, IL1B, IL1RN SLC1A5 3256/4885KIF11 4831/4885TAAR1 431/4885
US-20250090624-A1 MODULATORS OF COMPLEMENT ACTIVITY C3AR1, C1QBP, C5AR1 SLC1A5 3710/4885KIF11 4658/4885TAAR1 3214/4885
US-10435438-B2 Modulation of complement activity C5, C3AR1, CFH SLC1A5 4225/4885KIF11 4739/4885TAAR1 4241/4885
US-12558398-B2 Inflammatory disease treatment with complement inhibitors C5, C1R, SRPRB SLC1A5 4206/4885KIF11 1922/4885TAAR1 4688/4885
US-12239684-B2 Modulators of complement activity C3AR1, C1QBP, C5AR1 SLC1A5 3573/4885KIF11 4610/4885TAAR1 3303/4885
US-20160024159-A1 POTENT AND SELECTIVE INHIBITORS OF NAV1.7 SCN7A, SCN9A, SCN1A SLC1A5 1893/4885KIF11 3091/4885TAAR1 2165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.