Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675515 | 1.00 | CCKBR (0.48) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL29695279 | 1.00 | CCKBR (0.48) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL28295474 | 0.82 | CHRM1 (0.56) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL28297188 | 0.78 | CHRM1 (0.49) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL15622730 | 0.78 | MAPT (0.37) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL28749219 | 0.78 | NOTCH1 (0.35) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL29695118 | 0.78 | NOTCH1 (0.35) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL20098126 | 0.74 | CCKBR (0.46) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL11278577 | 0.72 | GABRA1 (0.47) | CCKBRCHRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL11278574 | 0.72 | GABRA1 (0.47) | CCKBRCHRM1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075515-A | Benzodiazepine derivatives useful for the treatment of respiratory syncytial virus infection | 辉瑞大药厂 | 2023-05-05 | — | — | CN | disclosed |
| CN-116075516-A | Benzodiazepine derivatives useful for the treatment of respiratory syncytial virus infection | 辉瑞大药厂 | 2023-05-05 | — | — | CN | disclosed |
| CN-114787155-A | Pharmaceutical compounds | 瑞威有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-114761397-A | Benzodiazepine derivatives for the treatment of Respiratory Syncytial Virus (RSV) infection | 瑞威有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114555604-A | Pharmaceutical compounds | 瑞威有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2019067864-A1 | COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2019-04-04 | — | — | WO | disclosed |
| CN-104968648-A | Prodrugs of 1, 4-benzodiazepinone compounds | BRISTOL MYERS SQUIBB CO | 2015-10-07 | — | — | CN | disclosed |
| CN-103717576-A | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds | BRISTOL MYERS SQUIBB CO | 2014-04-09 | — | — | CN | disclosed |
| CN-1933841-A | Pharmaceutical composition comprising a benzodiazepine derivative and an inhibitor of the rsv fusion protein | ARROW THERAPEUTICS LTD (GB) | 2007-03-21 | — | — | CN | disclosed |
| EP-1727551-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND A INHIBITOR OF THE RSV FUSION PROTEIN | Arrow Therapeutics Limited (GB) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005089771-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A BENZODIAZEPINE DERIVATIVE AND A INHIBITOR OF THE RSV FUSION PROTEIN | ARROW THERAPEUTICS LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |
| CN-1041941-A | The preparation method of benzodiazepine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-05-09 | — | — | CN | disclosed |