Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 12/20 | 0.50 |
| ▸ | HTR1D | P28221 | 12/20 | 0.50 |
| ▸ | HTR1B | P28222 | 12/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 4/20 | 0.48 |
| ▸ | HTR2B | P41595 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257865 | 0.86 | IDE (0.45) | HTR1AHTR1DHTR1BMEN1KMT2A | |
| SCHEMBL4010098 | 0.83 | MAPT (0.49) | HTR1AHTR2AHTR2CMEN1KMT2A | |
| SCHEMBL430227 | 0.82 | CYP2C9 (0.52) | CYP2C9HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL4178112 | 0.81 | NCF1 (0.59) | CYP2C9HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6065199 | 0.81 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTIDE | |
| SCHEMBL4176341 | 0.78 | CKS1B (0.53) | CYP2C9HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6472002 | 0.76 | HTR2A (0.48) | HTR1ADRD2HTR7HTR2AHTR2C | |
| SCHEMBL5238295 | 0.75 | MAPT (0.42) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL4710630 | 0.75 | MAPT (0.51) | CYP2C9MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11160876 | 0.73 | MEN1 (0.52) | CYP2C9MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646613-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005014552-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |