Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL4609059 | 1.00 | TSHR (0.60) | TSHRTP53SRD5A2ALDH1A1CA1 | |
| Terephthalic Acid SCHEMBL4605264 | 0.98 | TSHR (0.57) | TSHRTP53SRD5A2ALDH1A1CA1 | |
| Terephthalic Acid SCHEMBL4605471 | 0.93 | TSHR (0.52) | TSHRTP53SRD5A2ALDH1A1CA1 | |
| Benzoic Acid SCHEMBL28132510 | 0.91 | TSHR (0.64) | TSHRTP53SRD5A2ALDH1A1DAO | |
| Benzoic Acid SCHEMBL14890341 | 0.91 | TSHR (0.64) | TSHRTP53SRD5A2ALDH1A1DAO | |
| Terephthalic Acid SCHEMBL4625730 | 0.83 | TSHR (0.46) | TSHRTP53SRD5A2ALDH1A1CA1 | |
| Terephthalic Acid SCHEMBL7629401 | 0.83 | KMT2A (0.45) | TSHRTP53SRD5A2CA1CA2 | |
| Isophthalic Acid SCHEMBL4624459 | 0.82 | CA12 (0.52) | TSHRTP53CA1CA2CA12 | |
| Isophthalic Acid SCHEMBL8125692 | 0.82 | CA12 (0.52) | TSHRTP53CA1CA2CA12 | |
| Terephthalic Acid SCHEMBL332989 | 0.81 | TSHR (0.71) | TSHRTP53SRD5A2ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101649-B2 | Heat-sensitive lithographic printing plate | FUJI PHOTO FILM CO., LTD. (JP) | 2006-09-05 | — | — | US | disclosed |