Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.76 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568692 | 0.86 | DYRK1A (1.00) | DYRK1AGSK3BPIK3CGCSNK1DCSNK1G2 | |
| SCHEMBL13718453 | 0.83 | DYRK1A (0.74) | DYRK1AGSK3BPIK3CGCSNK1DCSNK1G2 | |
| SCHEMBL6067971 | 0.82 | DYRK1A (0.69) | DYRK1AGSK3BPIK3CGCSNK1DCSNK1G2 | |
| SCHEMBL23256870 | 0.81 | DYRK1A (0.70) | DYRK1AGSK3BCSNK1DCSNK1G2RAB9A | |
| SCHEMBL6068126 | 0.81 | DYRK1A (0.71) | DYRK1AGSK3BPIK3CGABL1RAB9A | |
| SCHEMBL21568049 | 0.81 | DYRK1A (0.76) | DYRK1AGSK3BPIK3CGCSNK1DCSNK1G2 | |
| SCHEMBL23256883 | 0.80 | DYRK1A (0.66) | DYRK1AGSK3BCSNK1DCSNK1G2RAB9A | |
| SCHEMBL21568123 | 0.79 | DYRK1A (0.65) | DYRK1AGSK3BCSNK1DCSNK1G2RAB9A | |
| SCHEMBL21568323 | 0.79 | DYRK1A (0.65) | DYRK1AGSK3BCSNK1DCSNK1G2RAB9A | |
| SCHEMBL23256895 | 0.79 | DYRK1A (0.68) | DYRK1AGSK3BCSNK1DCSNK1G2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091227-B2 | Benzothiazole derivatives | ABBOTT GMBH & CO. KG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20030153568-A1 | Benzothiazole derivatives | BASF AKTIENGESELLSCHAFT LUDWIGSHAFEN, GERMANY | 2003-08-14 | — | — | US | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153568-A1 | Benzothiazole derivatives | TK1, FLT1, CDK1 | DYRK1A 231/4885GSK3B 89/4885PIK3CG 376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.