Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21568692 | 0.82 | DYRK1A (1.00) | DYRK1ACSNK1DCSNK1G2GSK3BPIK3CG | |
| SCHEMBL6067966 | 0.82 | DYRK1A (0.76) | DYRK1ACSNK1DCSNK1G2GSK3BPIK3CG | |
| SCHEMBL21568049 | 0.82 | DYRK1A (0.76) | DYRK1ACSNK1DCSNK1G2GSK3BPIK3CG | |
| SCHEMBL23256870 | 0.79 | DYRK1A (0.70) | DYRK1ACSNK1DCSNK1G2GSK3BALDH1A1 | |
| SCHEMBL17987867 | 0.79 | DYRK1A (0.63) | DYRK1ACSNK1DCSNK1G2GSK3BPIK3CG | |
| SCHEMBL13718453 | 0.79 | DYRK1A (0.74) | DYRK1ACSNK1DCSNK1G2GSK3BPIK3CG | |
| SCHEMBL6068126 | 0.77 | DYRK1A (0.71) | DYRK1AGSK3BPIK3CGABL1NPC1 | |
| SCHEMBL23256883 | 0.76 | DYRK1A (0.66) | DYRK1ACSNK1DCSNK1G2GSK3BALDH1A1 | |
| SCHEMBL21568958 | 0.76 | DYRK1A (0.65) | DYRK1ACSNK1DCSNK1G2GSK3BPIK3CG | |
| SCHEMBL21568955 | 0.76 | GSK3B (0.76) | DYRK1AGSK3BABL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091227-B2 | Benzothiazole derivatives | ABBOTT GMBH & CO. KG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20030153568-A1 | Benzothiazole derivatives | BASF AKTIENGESELLSCHAFT LUDWIGSHAFEN, GERMANY | 2003-08-14 | — | — | US | disclosed |
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153568-A1 | Benzothiazole derivatives | TK1, FLT1, CDK1 | DYRK1A 231/4885CSNK1D 74/4885CSNK1G2 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.