Ethisterone

Ethisterone

SCHEMBL606819

C#C[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 8/20 1.00
SHBG P04278 7/20 1.00
SMN1; SMN2 Q16637 5/20 1.00
TSHR P16473 5/20 1.00
NR3C1 P04150 4/20 1.00
CYP2C19 P33261 4/20 1.00
PGR P06401 3/20 1.00
HIF1A Q16665 3/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
ESR1 P03372 2/20 1.00
THRB P10828 1/20 1.00
AR P10275 1/20 1.00
ALDH1A1 P00352 4/20 0.72
ADRA1A P35348 1/20 0.72
HTR2B P41595 1/20 0.72
BLM P54132 5/20 0.67
SERPINA6 P08185 4/20 0.67
MAPT P10636 3/20 0.67
ADORA3 P0DMS8 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethisterone SCHEMBL7604035 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL15581276 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL14433089 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL12417537 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL24475 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL16864523 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL16691330 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL780055 1.00 LMNA (1.00) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL28541256 0.99 LMNA (0.98) LMNASHBGSMN1; SMN2TSHRNR3C1
Ethisterone SCHEMBL11152514 0.96 LMNA (0.92) LMNASHBGSMN1; SMN2TSHRNR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8617100-B2 Device for delivery of a foamable composition FOAMIX LTD. (IL) 2013-12-31 US claimed
WO-2009056991-A2 DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION FOAMIX LTD. (US) 2009-05-07 WO claimed
US-20090068118-A1 DEVICE FOR DELIVERY OF A FOAMABLE COMPOSITION FOAMIX LTD. (IL) 2009-03-12 US claimed
US-20040266025-A1 Screening and treatment methods for prevention of preterm delivery CYTYC CORPORATION 2004-12-30 US claimed
US-4749649-A Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen THE UPJOHN COMPANY (US) 1988-06-07 US claimed
US-4684610-A ARTHROBACTER OR BACTERIUM THE UPJOHN COMPANY (US) 1987-08-04 US claimed
EP-0127294-B1 STEROID DEHYDROGENATION THE UPJOHN COMPANY (US) 1986-12-17 EP claimed
EP-0053845-B1 17-BETA-ETHYNYLSTEROIDS AND PROCESS FOR PREPARING SAME MITSUBISHI KASEI CORPORATION (JP) 1985-04-10 EP claimed
EP-0127294-A1 Steroid dehydrogenation THE UPJOHN COMPANY (US) 1984-12-05 EP claimed
EP-0053845-A1 17-Beta-ethynylsteroids and process for preparing same MITSUBISHI KASEI CORPORATION (JP) 1982-06-16 EP claimed
EP-2299275-B1 Classification of the oncofetal fibronection level for pregnancy-related indications ADEZA BIOMEDICAL CORP (US) 2018-03-07 EP disclosed
US-9513298-B2 Methods for detecting oncofetal fibronectin BANK OF AMERICA, N.A., AS COLLATERAL AGENT 2016-12-06 US disclosed
EP-2462959-B1 Methods and products for treatment of diseases AMPIO PHARMACEUTICALS INC (US) 2016-06-22 EP disclosed
US-20150044708-A1 Methods for Detecting Oncofetal Fibronectin HOLOGIC, INC. 2015-02-12 US disclosed
US-8852872-B2 Methods for detecting oncofetal fibronectin HOLOGIC, INC. (US) 2014-10-07 US disclosed
US-4180064-A HYDROPHOBIC POLYMERS WITH CARBOXYLIC ACID GROUPS ALZA CORPORATION (US) 1979-12-25 US disclosed
US-4014987-A VAGINAL DEVICE; USING A HYDROPHOBIC POLYCARBOXYLIC ACID AS DRUG RELEASE RATE CONTROLLER ALZA CORPORATION (US) 1977-03-29 US disclosed
US-3993057-A Intrauterine device that bioerodes in response to the environment of the uterus and method of using ALZA CORPORATION (US) 1976-11-23 US disclosed
US-3971367-A Intrauterine device having means for changing from uterine-retentive shape to nonuterine-retentive shape ALZA CORPORATION (US) 1976-07-27 US disclosed
US-3935860-A Intrauterine device with restrictor for maintaining device in uterine cavity ALZA CORPORATION (US) 1976-02-03 US disclosed