Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068469 | 0.87 | POLB (0.45) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068481 | 0.81 | POLB (0.46) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068301 | 0.81 | POLB (0.43) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL7243220 | 0.79 | MAPT (0.46) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068610 | 0.79 | POLB (0.44) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068459 | 0.79 | POLB (0.44) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068443 | 0.77 | POLB (0.41) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL7247653 | 0.73 | MAPT (0.37) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068240 | 0.69 | MAPT (0.40) | POLBMAPTTP53RXFP1NPSR1 | |
| SCHEMBL6068576 | 0.69 | GABRA1 (0.59) | PKMALDH1A1LMNAGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |