Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068610 | 0.92 | POLB (0.44) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL6068301 | 0.86 | POLB (0.43) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL6068256 | 0.77 | POLB (0.44) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL6068469 | 0.76 | POLB (0.45) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL7242372 | 0.72 | MAPT (0.46) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL6068643 | 0.71 | KMT2A (0.37) | MAPTRXFP1PKMKMT2AMEN1 | |
| SCHEMBL6068549 | 0.70 | MEN1 (0.45) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL7243828 | 0.65 | POLB (0.47) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL6068521 | 0.65 | KDM4E (0.41) | POLBMAPTNPSR1TP53RXFP1 | |
| SCHEMBL6068520 | 0.65 | HPGD (0.51) | POLBMAPTNPSR1TP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |