Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7243220 | 0.91 | MAPT (0.46) | MAPTKDM4EALDH1A1XBP1MAPK1 | |
| SCHEMBL7245156 | 0.77 | MAPT (0.46) | MAPTKDM4EALDH1A1XBP1MAPK1 | |
| SCHEMBL6068256 | 0.73 | POLB (0.44) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL7243558 | 0.73 | MAPT (0.46) | MAPTKDM4EALDH1A1XBP1MAPK1 | |
| SCHEMBL7242486 | 0.72 | MAPT (0.48) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL7243226 | 0.71 | MAPT (0.49) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL7242624 | 0.71 | MAPT (0.65) | MAPTALDH1A1TP53RXFP1POLB | |
| SCHEMBL7241576 | 0.70 | MAPT (0.47) | MAPTKDM4EALDH1A1XBP1MAPK1 | |
| SCHEMBL7243828 | 0.70 | POLB (0.47) | MAPTKDM4EALDH1A1XBP1MAPK1 | |
| SCHEMBL7242372 | 0.69 | MAPT (0.46) | MAPTKDM4EALDH1A1XBP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-06 | — | — | US | claimed |
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045532-A1 | Triazolo-pyrimidine derivatives as ligands for gaba receptors | GABRA3, GABRA2, GABRA4 | MAPT 1447/4885KDM4E 3611/4885ALDH1A1 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.