Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 12/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 11/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068706 | 0.83 | POLB (0.36) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068567 | 0.82 | MAPT (0.36) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068244 | 0.73 | RXFP1 (0.51) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068830 | 0.72 | RXFP1 (0.50) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068798 | 0.71 | RXFP1 (0.51) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068524 | 0.71 | RXFP1 (0.51) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068619 | 0.71 | RXFP1 (0.51) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068552 | 0.71 | RXFP1 (0.49) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068562 | 0.71 | RXFP1 (0.49) | RXFP1MEN1KMT2ATP53MAPT | |
| SCHEMBL6068773 | 0.71 | RXFP1 (0.50) | RXFP1MEN1KMT2ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |