Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 12/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 12/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068244 | 0.85 | RXFP1 (0.51) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068619 | 0.83 | RXFP1 (0.51) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068798 | 0.83 | RXFP1 (0.51) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068773 | 0.83 | RXFP1 (0.50) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068562 | 0.81 | RXFP1 (0.49) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068552 | 0.81 | RXFP1 (0.49) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068830 | 0.80 | RXFP1 (0.50) | RXFP1POLBTP53KDM4ENPSR1 | |
| SCHEMBL6068550 | 0.71 | RXFP1 (0.47) | RXFP1POLBTP53KDM4EMAPT | |
| SCHEMBL6068576 | 0.71 | GABRA1 (0.59) | ALDH1A1 | |
| SCHEMBL6068240 | 0.70 | MAPT (0.40) | RXFP1POLBTP53KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |