Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 11/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6068773 | 0.84 | RXFP1 (0.50) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068711 | 0.83 | GABRA1 (0.46) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068712 | 0.83 | GABRA1 (0.46) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068244 | 0.83 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068562 | 0.82 | RXFP1 (0.49) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068571 | 0.82 | MAPT (0.41) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068619 | 0.81 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068798 | 0.81 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068524 | 0.81 | RXFP1 (0.51) | RXFP1POLBTP53MAPTKDM4E | |
| SCHEMBL6068830 | 0.78 | RXFP1 (0.50) | RXFP1POLBTP53MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | claimed |
| US-7144887-B2 | Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition | MERCK SHARP & DOHME LTD. (GB) | 2006-12-05 | — | — | US | disclosed |