Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 18/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 18/20 | 0.48 |
| ▸ | ITGAL | P20701 | 18/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426358 | 0.84 | ITGB2 (0.47) | ITGB2ICAM1ITGALMEN1ALDH1A1 | |
| SCHEMBL6197314 | 0.78 | ITGB2 (0.48) | ITGB2ICAM1ITGAL | |
| SCHEMBL6956020 | 0.75 | ITGB2 (0.53) | ITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL30389926 | 0.74 | GABRA1 (0.48) | ITGB2ICAM1ITGAL | |
| SCHEMBL4808650 | 0.74 | GABRA1 (0.48) | ITGB2ICAM1ITGAL | |
| SCHEMBL18522893 | 0.73 | GABRA1 (0.43) | KMT2A | |
| SCHEMBL5421581 | 0.72 | ITGB2 (0.50) | ITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL7021938 | 0.72 | ITGB2 (0.44) | ITGB2ICAM1ITGAL | |
| SCHEMBL7143425 | 0.72 | ITGAL (0.74) | ITGB2ICAM1ITGAL | |
| SCHEMBL1635308 | 0.70 | GABRA1 (0.50) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | WANG GARY T | 2007-03-22 | — | — | US | disclosed |
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | WANG GARY T | 2007-03-22 | — | — | US | disclosed |
| US-7129247-B2 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | ABBOTT LABORATORIES (US) | 2006-10-31 | — | — | US | disclosed |
| US-6787542-B2 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | ICOS CORPORATION | 2004-09-07 | — | — | US | disclosed |
| EP-1294704-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | ABBOTT LABORATORIES (US) | 2003-03-26 | — | — | EP | disclosed |
| US-20020132807-A1 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | ICOS CORPORATION | 2002-09-19 | — | — | US | disclosed |
| WO-2002002539-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | ABBOTT LABORATORIES (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020132807-A1 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents | VCAM1, ICAM1, CD47 | ITGB2 70/4885ICAM1 2/4885ITGAL 97/4885 |
| US-20070066585-A1 | ARYL PHENYLHETEROCYCLYL SULFIDE DERIVATIVES AND THEIR USE AS CELL ADHESION-INHIBITING ANTI-INFLAMMATORY AND IMMUNE-SUPPRESSIVE AGENTS | VCAM1, ICAM1, CD47 | ITGB2 70/4885ICAM1 2/4885ITGAL 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.