Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 8/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.69 |
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | DDX3X | O00571 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5141415 | 0.89 | MEN1 (0.75) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL9670363 | 0.88 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL1969093 | 0.84 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL28929464 | 0.84 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL30069319 | 0.84 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL5213509 | 0.84 | CYP1A2 (0.78) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL9427754 | 0.84 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL30957465 | 0.84 | CYP1A2 (0.78) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL8752436 | 0.83 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL18530327 | 0.83 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6991902-B2 | Nucleobase heterocyclic combinatorialization | ISIS PHARMACEUTICALS, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| US-20050288347-A1 | Certain triazole-based compounds, compositions, and uses thereof | AGRIUS GROUP, LLC. | 2005-12-29 | — | — | US | disclosed |
| US-6893815-B1 | Nucleobase heterocyclic combinatorialization | ISIS PHARMACEUTICALS, INC. (US) | 2005-05-17 | — | — | US | disclosed |
| US-20030003505-A1 | Nucleobase heterocyclic combinatorialization | ISIS PHARMACEUTICALS, INC. | 2003-01-02 | — | — | US | disclosed |
| US-20020009748-A1 | NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION | ISIS PHARMACEUTICALS, INC. | 2002-01-24 | — | — | US | disclosed |
| WO-1999000669-A1 | NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1999-01-07 | — | — | WO | disclosed |
| WO-1998006671-A1 | METHODS FOR REMOVING UNREACTED ELECTROPHILES FROM A REACTION MIXTURE | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-19 | — | — | WO | disclosed |
| US-5632898-A | SCAVINGING WITH A WATER-SOLUBLE NUCLEOPHILE COMPRISING AMINO-, HYDROXY- OR MERCAPTO-CONTAINING SULFONATES, CARBOXYLATES OR PHOSPHONATES FOLLOWED BY SEPARATION | ISIS PHARMACEUTICALS, INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-4026709-A | Color photographic recording material | CIBA-GEIGY AG (CH) | 1977-05-31 | — | — | US | disclosed |
| US-3984432-A | PHOSPHONIC ACID AND PHOSPHORIC ACID DERIVATIVES | CIBA-GEIGY AG (CH) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020009748-A1 | NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION | PNP, ATIC, DPYD | ALDH1A1 1826/4885SMN1; SMN2 894/4885MEN1 971/4885 |
| US-20030003505-A1 | Nucleobase heterocyclic combinatorialization | PNP, ATIC, DPYD | ALDH1A1 1826/4885SMN1; SMN2 894/4885MEN1 971/4885 |
| US-20050288347-A1 | Certain triazole-based compounds, compositions, and uses thereof | ABCG2, ATP5ME, DNTT | ALDH1A1 720/4885SMN1; SMN2 4793/4885MEN1 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.