Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8194555 | 0.85 | ALDH1A1 (0.43) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL8198297 | 0.85 | ALDH1A1 (0.43) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL15337139 | 0.83 | RET (0.53) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL6378864 | 0.82 | ALDH1A1 (0.44) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL938191 | 0.81 | KMT2A (0.39) | KMT2ARAB9AKDM4EALDH1A1TSHR | |
| SCHEMBL24530273 | 0.80 | KMT2A (0.49) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL13236669 | 0.80 | ALDH1A1 (0.50) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL176995 | 0.79 | POLB (0.44) | KMT2ARAB9ARETKDRKDM4E | |
| Maleic Acid SCHEMBL8496585 | 0.78 | ALDH1A1 (0.39) | KMT2ARAB9ARETKDRKDM4E | |
| SCHEMBL11973927 | 0.78 | KMT2A (0.50) | KMT2ARAB9AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074930-B2 | Amine salts of an integrin receptor antagonist | MERCK & CO., INC (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1444231-A4 | AMINE SALTS OF AN INTEGRIN RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6916810-B2 | αν integrin receptor antagonists | MERCK & CO., INC. (US) | 2005-07-12 | — | — | US | disclosed |
| US-20040249158-A1 | Amine salts of an integrin receptor antagonist | MERCK & CO., INC. | 2004-12-09 | — | — | US | disclosed |
| US-20040192670-A1 | Alpha v integrin receptor antagonists | MERCK & CO., INC. | 2004-09-30 | — | — | US | disclosed |
| EP-1444231-A1 | AMINE SALTS OF AN INTEGRIN RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040143-A1 | AMINE SALTS OF AN INTEGRIN RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192670-A1 | Alpha v integrin receptor antagonists | ITGAV, ITGA5, ITGB5 | KMT2A 4592/4885RAB9A 907/4885RET 793/4885 |
| US-20040249158-A1 | Amine salts of an integrin receptor antagonist | ITGB3, ITGA1, ITGAL | KMT2A 3066/4885RAB9A 1281/4885RET 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.