Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.62 |
| ▸ | GAK | O14976 | 5/20 | 0.62 |
| ▸ | SYK | P43405 | 2/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | ILK | Q13418 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | BUB1 | O43683 | 1/20 | 0.62 |
| ▸ | KDM1A | O60341 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.62 |
| ▸ | STK17B | O94768 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813040 | 0.90 | EGFR (0.50) | EGFRERBB2GAKSYKBRAF | |
| SCHEMBL27669463 | 0.79 | EGFR (0.63) | EGFRERBB2GAKSYKBRAF | |
| SCHEMBL13815419 | 0.78 | EGFR (0.67) | EGFRERBB2GAKSYKBRAF | |
| SCHEMBL23196396 | 0.77 | EGFR (0.72) | EGFRERBB2GAKSYKBRAF | |
| Erlotinib SCHEMBL3667407 | 0.77 | EGFR (1.00) | EGFRERBB2GAKSYKBRAF | |
| Erlotinib SCHEMBL29351329 | 0.77 | EGFR (1.00) | EGFRERBB2GAKSYKBRAF | |
| Erlotinib SCHEMBL8413 | 0.77 | EGFR (1.00) | EGFRERBB2GAKSYKBRAF | |
| SCHEMBL29749690 | 0.77 | EGFR (1.00) | EGFRERBB2GAKSYKBRAF | |
| Erlotinib SCHEMBL30362833 | 0.77 | EGFR (1.00) | EGFRERBB2GAKSYKBRAF | |
| SCHEMBL13824816 | 0.77 | EGFR (1.00) | EGFRERBB2GAKSYKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192876-A1 | DOSING REGIMEN OF ANTI-CD27 ANTIBODIES FOR TREATMENT OF CANCER | MERCK SHARP & DOHME CORP. (US) | 2023-06-22 | — | — | US | disclosed |
| US-20060234984-A1 | Kinesin spindle protein (KSP) inhibitors, e.g., 4-(2,5-Difluorophenyl)-N-[(3S,4S)-3-fluoropiperidin-4-yl]-2-hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1N-pyrrole-1-carboxamide, and a carrier; antiproliferative and -carcinogenic agents; side effects reduction; used with an estrogen receptor modulator | MERCK & CO., INC. | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060234984-A1 | Kinesin spindle protein (KSP) inhibitors, e.g., 4-(2,5-Difluorophenyl)-N-[(3S,4S)-3-fluoropiperidin-4-yl]-2-hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1N-pyrrole-1-carboxamide, and a carrier; antiproliferative and -carcinogenic agents; side effects reduction; used with an estrogen receptor modulator | KIF5B, KIF2C, KIF5C | EGFR 1696/4885ERBB2 1046/4885GAK 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.