Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.59 |
| ▸ | DRD1 | P21728 | 6/20 | 0.59 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | DRD4 | P21917 | 5/20 | 0.59 |
| ▸ | DRD5 | P21918 | 5/20 | 0.59 |
| ▸ | PNMT | P11086 | 2/20 | 0.46 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694554 | 0.98 | DRD2 (0.61) | DRD2DRD1DRD3DRD4DRD5 | |
| Bromide SCHEMBL1648391 | 0.93 | DRD2 (0.59) | DRD2DRD1DRD3DRD4DRD5 | |
| SCHEMBL5418872 | 0.91 | DRD2 (0.61) | DRD2DRD1DRD3DRD4DRD5 | |
| Bromide SCHEMBL587893 | 0.89 | DRD2 (0.61) | DRD2DRD1DRD3DRD4DRD5 | |
| SCHEMBL29514775 | 0.86 | DRD2 (0.62) | DRD2DRD1DRD3DRD4DRD5 | |
| SCHEMBL1017452 | 0.86 | DRD2 (0.62) | DRD2DRD1DRD3DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL31336072 | 0.85 | DRD2 (0.61) | DRD2DRD1DRD3DRD4DRD5 | |
| Hydrochloric Acid SCHEMBL453336 | 0.85 | DRD2 (0.61) | DRD2DRD1DRD3DRD4DRD5 | |
| Bromide SCHEMBL6190676 | 0.81 | PNMT (0.63) | DRD2DRD1DRD3DRD4DRD5 | |
| Bromide SCHEMBL383952 | 0.80 | DRD2 (0.44) | DRD2DRD1DRD3DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089347-A1 | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2006-04-27 | — | — | US | disclosed |
| EP-1539704-A1 | SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018432-A1 | SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089347-A1 | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses | HRH3, HRH4, HRH2 | DRD2 595/4885DRD1 968/4885DRD3 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.