Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | EGLN2 | Q96KS0 | 5/20 | 0.43 |
| ▸ | FYN | P06241 | 5/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5946455 | 0.97 | DYRK3 (0.47) | DYRK1ADYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL29941012 | 0.80 | DYRK1A (0.62) | DYRK1ADYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL11463687 | 0.80 | EGLN2 (0.58) | DYRK1ACDK2DYRK1BEGLN2FYN | |
| SCHEMBL11473783 | 0.79 | EGLN2 (0.68) | EGLN2 | |
| SCHEMBL10553161 | 0.78 | KDM4E (0.57) | DYRK1ADYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL11470945 | 0.77 | KDM4C (0.52) | DYRK1ADYRK3DYRK2DYRK1BFYN | |
| SCHEMBL4655958 | 0.76 | MAPT (0.57) | DYRK1ADYRK3CCNT1CCNA2CDK2 | |
| SCHEMBL6071500 | 0.76 | EGLN2 (0.51) | DYRK1AEGLN2FYNPDE4DAAK1 | |
| SCHEMBL5946454 | 0.75 | EGLN2 (0.39) | DYRK1ACDK2EGLN2FYNPDE4D | |
| SCHEMBL6071178 | 0.75 | MAPKAPK2 (0.42) | DYRK1AEGLN2FYNMEN1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063784-A1 | Method of using substituted pyrazolo [1,5-a] pyrimidines | WYETH | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063784-A1 | Method of using substituted pyrazolo [1,5-a] pyrimidines | TYMP, DPYD, TYMS | DYRK1A 1162/4885DYRK3 1445/4885CCNT1 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.