Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD5 | P21918 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471625 | 0.91 | PRMT5 (0.48) | PRMT5WDR77MAOAMAOBPRKCI | |
| SCHEMBL29438592 | 0.91 | PRMT5 (0.48) | PRMT5WDR77MAOAMAOBPRKCI | |
| SCHEMBL31409528 | 0.81 | ADAM17 (0.48) | PRMT5WDR77MAOAMAOBPRKCI | |
| SCHEMBL6071362 | 0.80 | PRMT5 (0.57) | PRMT5WDR77DRD1DRD2DRD5 | |
| SCHEMBL5946849 | 0.80 | GRM5 (0.52) | PRMT5WDR77MAOAMAOBPRKCI | |
| SCHEMBL25896981 | 0.79 | GRM5 (0.61) | PRMT5WDR77MAOAMAOBPRKCI | |
| SCHEMBL29322833 | 0.78 | DRD3 (0.51) | DRD1DRD2DRD4DRD3 | |
| SCHEMBL8731853 | 0.78 | HRH3 (0.51) | CHRM2CHRM4DRD1DRD2DRD5 | |
| SCHEMBL8548891 | 0.77 | PRMT5 (0.53) | PRMT5WDR77MAOAMAOBDRD1 | |
| SCHEMBL4400467 | 0.75 | CHRM2 (0.61) | CHRM2CHRM4DRD1DRD2DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089347-A1 | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2006-04-27 | — | — | US | disclosed |
| EP-1539704-A1 | SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018432-A1 | SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089347-A1 | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses | HRH3, HRH4, HRH2 | PRMT5 270/4885WDR77 266/4885MAOA 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.