Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 11/20 | 0.51 |
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.50 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.50 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31337054 | 0.84 | ALDH1A1 (0.67) | RAB9ANPC1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6282033 | 0.84 | ALDH1A1 (0.67) | RAB9ANPC1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3967062 | 0.82 | KDM4E (0.73) | GSK3BRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL6071536 | 0.82 | GSK3B (0.54) | GSK3BRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL6071449 | 0.79 | KDM4E (0.75) | GSK3BRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL6207703 | 0.77 | SLC2A1 (0.58) | GSK3BRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL6204755 | 0.77 | GSK3B (0.54) | GSK3BRAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL6205850 | 0.77 | TP53 (0.62) | ALDH1A1KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL12000977 | 0.76 | ALDH1A1 (0.41) | RAB9ANPC1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6206486 | 0.75 | GSK3B (0.60) | GSK3BRAB9ANPC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060167020-A1 | Pyrazolopyrimidines as kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167020-A1 | Pyrazolopyrimidines as kinase inhibitors | MAP3K12, MAP3K5, MAP3K2 | GSK3B 591/4885RAB9A 2641/4885NPC1 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.